Abstract
Five X-ray crystal structures of scytalone dehydratase complexed with different inhibitors have delineated conformationally flexible regions of the binding pocket. This information was used for the design and synthesis of a norephedrine-derived cyanoacetamide class of inhibitors leading to potent fungicides.
MeSH terms
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Antifungal Agents / chemical synthesis*
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Crystallography, X-Ray
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Hydro-Lyases / antagonists & inhibitors*
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Kinetics
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Models, Chemical
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Models, Molecular
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Phenylpropanolamine / analogs & derivatives*
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Phenylpropanolamine / chemical synthesis*
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Plant Diseases
Substances
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Antifungal Agents
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Phenylpropanolamine
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Hydro-Lyases
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scytalone dehydratase